Summary and comparison of the perforin in teleosts and mammals: A review

Abstract Perforin, a pore‐forming glycoprotein, has been demonstrated to play key roles in clearing virus‐infected cells and tumour due its ability of forming ‘pores’ on the cell membranes. Additionally, perforin is also found be associated with human diseases such as tumours, virus infections, immune rejection some autoimmune diseases. Until now, plenty genes have identified vertebrates, especially mammals teleost fish. Conversely, vertebrate homologue gene was not invertebrates. Although recently there several reviews focusing granzymes mammals, no one highlighted current advances other vertebrates. Here, addition mammalian perforin, structure, evolution, tissue distribution function bony fish are summarized, respectively, which will allow us gain more insights into lower animals evolution this important protein across